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Severe Combined Immunodeficiency Disease

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Severe Combined Immunodeficiency Disease, X-linked Trial in San Francisco, Memphis, Seattle (genetic, drug, device)

Recruiting
  • Severe Combined Immunodeficiency Disease, X-linked
  • CL20-i4-EF1α-hγc-OPT
  • +2 more
  • San Francisco, California
  • +2 more
Jan 9, 2023

Evaluation of Patients With Immune Function Abnormalities

Recruiting
  • Chronic Granulomatous Disease (CGD)
  • +3 more
    • Bethesda, Maryland
      National Institutes of Health Clinical Center, 9000 Rockville Pi
    Aug 24, 2022

    Severe Combined Immunodeficiency (SCID), Immunodeficiency With Predominant T-cell Defect, Unspecified, Severe Chronic

    Enrolling by invitation
    • Severe Combined Immunodeficiency (SCID)
    • +8 more
    • CD3/CD19 negative allogeneic hematopoietic stem cells
    • Pittsburgh, Pennsylvania
      Children's Hospital of Pittsburgh of UPMC
    Dec 6, 2021

    Immune Deficiency Disorders, Severe Combined Immunodeficiency, Chronic Granulomatous Disease Trial in Saint Louis (Transplant

    Recruiting
    • Immune Deficiency Disorders
    • +13 more
    • Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan
    • Saint Louis, Missouri
      Washington University
    Apr 25, 2022

    Genetic Basis of Immunodeficiency

    Recruiting
    • Severe Combined Immunodeficiency
      • Bethesda, Maryland
        National Institutes of Health Clinical Center
      Jan 21, 2023

      X-linked Severe Combined Immunodeficiency (XSCID) Trial run by the National Institute of Allergy and Infectious Diseases (NIAID)

      Suspended
      • X-linked Severe Combined Immunodeficiency (XSCID)
      • Bethesda, Maryland
        National Institutes of Health Clinical Center, 9000 Rockville Pi
      Aug 24, 2022

      Bone Marrow Failure Syndrome, Thalassemia, Sickle Cell Disease Trial in Gainesville (Thiotepa--single daily dose,

      Recruiting
      • Bone Marrow Failure Syndrome
      • +15 more
      • Thiotepa--single daily dose
      • Thiotepa--escalated dose
      • Gainesville, Florida
        UF Health Shands Children's Hospital
      Jul 8, 2021

      The Experience of Screening for SCID

      Recruiting
      • Severe Combined Immunodeficiency
      • SCID Screening
      • London, United Kingdom
        King's College London
      Dec 6, 2022

      Neonatal Screening of Severe Combined Immunodeficiencies

      Completed
      • Severe Combined Immunodeficiency
      • Neonatal Screening
        • Shanghai, Shanghai, China
          Children's Hospital of Fudan University
        Jan 3, 2022

        Artemis (DCLRE1C ) Deficient Severe Combined Immunodeficiency Trial in Paris (ARTEGENE drug product)

        Not yet recruiting
        • Artemis (DCLRE1C ) Deficient Severe Combined Immunodeficiency
        • ARTEGENE drug product
        • Paris, France
          Department of Pediatric Immunology, Hematology and Rheumatology
        Sep 26, 2022

        X-linked Severe Combined Immunodeficiency Trial in Paris (Gene transfer)

        Completed
        • X-linked Severe Combined Immunodeficiency
        • Gene transfer
        • Paris, France
          Hopital Necker
        Sep 22, 2021

        Severe Combined Immunodeficiency Trial in San Francisco (AProArt, CliniMACS® CD34 Reagent System cell sorter device, Busulfan)

        Recruiting
        • Severe Combined Immunodeficiency
        • San Francisco, California
          University of California, San Francisco (UCSF) Children's Hospit
        Feb 4, 2022

        Severe Combined Immunodeficiency, X-Linked Trial in London (Lentiviral vector transduced CD34+ cells)

        Recruiting
        • Severe Combined Immunodeficiency, X-Linked
        • Lentiviral vector transduced CD34+ cells
        • London, Greater London, United Kingdom
          Great Ormond Street Hospital for Children NHS Foundation Trust
        Mar 15, 2022

        Severe Combined Immune Deficiency (SCID) Trial run by the National Institute of Allergy and Infectious Diseases (NIAID)

        Enrolling by invitation
        • Severe Combined Immune Deficiency (SCID)
        • Bethesda, Maryland
          National Institutes of Health Clinical Center
        Aug 24, 2022

        Severe Combined Immunodeficiency Trial in Memphis (drug, device, other)

        Recruiting
        • Severe Combined Immunodeficiency
        • Anti-thymocyte globulin (rabbit)
        • +5 more
        • Memphis, Tennessee
          St. Jude Children's Research Hospital
        Oct 6, 2021

        Cord Blood Stem Cell Transplantation for SCID

        Active, not recruiting
        • Severe Combined Immunodeficiency Disease
        • cord blood stem cell transplantation
        • Shanghai, Minhang, China
          Children's Hospital of Fudan University
        Jan 25, 2020

        Severe Combined Immunodeficiency Due to ADA Deficiency Trial in Milan (STRIMVELIS)

        Completed
        • Severe Combined Immunodeficiency Due to ADA Deficiency
        • Milan, Italy
          Ospedale San Raffaele - Telethon Institute for Gene Therapy (OSR
        Feb 18, 2022

        Immunologic Deficiency Syndromes Trial in Milano (Strimvelis)

        Enrolling by invitation
        • Immunologic Deficiency Syndromes
        • Strimvelis
        • Milano, Lombardia, Italy
          Orchard Investigational Site
        Jun 23, 2021

        Severe Combined Immunodeficiency Due to RAG1 Deficiency Trial in Leiden (Gene therapy)

        Recruiting
        • Severe Combined Immunodeficiency Due to RAG1 Deficiency
        • Gene therapy
        • Leiden, Netherlands
          Leiden University Medical Center
        Dec 3, 2021

        Haematological Malignancy, Acute Leukemia, MDS Trial in Lyon (Physical activity program)

        Not yet recruiting
        • Haematological Malignancy
        • +5 more
        • Physical activity program
        • Lyon, France
          Institut d'Hématologie et d'Oncologie Pédiatrique
        Mar 25, 2022

        Sarcopenia, COPD, ILD Trial in Taichung (Sarcojoint®, supervised exercise)

        Recruiting
        • Sarcopenia
        • +2 more
        • Sarcojoint®
        • supervised exercise
        • Taichung, Taiwan
          Taichung Veterans General Hospital
        Jun 21, 2023

        Crohn Disease Trial (Upadacitinib, Vedolizumab)

        Not yet recruiting
        • Crohn Disease
        • (no location specified)
        Oct 18, 2023

        Severe Combined Immunodeficiency, X Linked, Gene Therapy Trial in United Kingdom, United States (autologous CD34+ cell

        Recruiting
        • Severe Combined Immunodeficiency, X Linked
        • Gene Therapy
        • autologous CD34+ cell transduced with G2SCID vector
        • Los Angeles, California
        • +4 more
        Jul 19, 2022

        Haematological Malignancy, Acute Leukemia, MDS Trial in Lyon (Physical activity program)

        Withdrawn
        • Haematological Malignancy
        • +5 more
        • Physical activity program
        • Lyon, France
          Institut d'Hématologie et d'Oncologie Pédiatrique
        Feb 10, 2022

        Patients Who Have Received Gene Therapy Or Gene Marked Products

        Recruiting
        • Severe Combined Immunodeficiency
        • +4 more
        • Venipuncture
        • Memphis, Tennessee
          St. Jude Children's Research Hospital
        Dec 10, 2021